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L1, Anxiolytics and sedative-hypnotic - Pharmacology

  Anxiolytics and sedative-hypnotic

 Lecture video





Questions

MCQ

GABA (A) receptors acts through (27)  

  1. a- presynaptic inhibition of ca influx
  2.  b- post synaptic inhibition by increasing k outflux
  3. c-by increasing Cl influx in postsynaptic neurons 
  4. d- all of the above


mechanism of action of BDZ ( 28 )

  1. a- direct stimulation of GABA receptors
  2. b- act as GABA potentiators
  3. c- increasing serotonin reuptake 
  4. d- all


 

all are short acting BDZ except ( 29 )

  1. a- midazolam
  2. b- triazolam
  3. c- lorazepam 
  4. d- oxazepam

which of the following is long acting BDZ ( 30 )

  1. a- diazepam 
  2. b- lorazepam
  3. c-temazepam 
  4. d- non


BDZ increases…….. of opening CL channels while barbits increases the ……. (31)

  1. a- duration – frequency
  2. b- frequency – duration 
  3. c- frequency&duration – duration only
  4. d- frequency&duration – frequency only

(32) BDZ are more powerfull than barbits because it 

  1. a- has direct mimetic effect on GABA receptors
  2. b- has additional glutamate receptor inhibition effect
  3. c- all 
  4. d- non

(33) all of the following are uses of BDZs except

  1. a-anticonvulsant
  2. b- preanathetic
  3. c- sedation 
  4. d- non

(34) Alprazolam is more selective in ………., Diazepam in…….

  1. a- epilepsy- convulsions
  2. b- muscle spasticity - panic
  3. c- panic attacks- muscle spasticity

(35) signs of toxicity of BDZs

  1. a- insomnia 
  2. b- respiratory depression
  3. c- cardiac depression 
  4. d- all
  5. e- b&C


 ( 36 ) antidote of BDz  

  1. a-buspiron
  2. b- flumazenil
  3. c- ramelteon
  4. d- flouxitin

(37) BDZs are more preferred than barbits because 

  1. a- more safer
  2. b- less addiction
  3. c- have specific antidote
  4. d-all

(38) non BDZ ultrashort hypnotic works on GABA receptors

  1. a- flumazenil 
  2. b- buspiron 
  3. c- zolpidem
  4. d- ramelteon

(39) selective anxiolytic inhibits 5HT release

  1. a- flumazenil 
  2. b- buspiron 
  3. c- zolpidem
  4. d- ramelteon

(40) hypnotic melatonin receptor agonist

  1. a- flumazenil 
  2. b- buspiron
  3. c- zolpidem
  4. d- ramelteon


(41) pharmacological action of barbiturates

  1. a-enhancing action of BDZ
  2. b- direct action on GABA receptors
  3. c- inhibits effect of glutamate receptors
  4. d- all of the following

(42) most effective BDZ used in panic attacks

  1. a- diazepam 
  2. b- alprazolam
  3. c- clonazepam 
  4. d- lorazepam

(43) therabutic uses of flumazenil 

  1. a- BDZ toxicity 
  2. b- barbits toxicity
  3. c- Termination of BZDs effects in anesthesia
  4. d- convulsions in BZDs dependent patients
  5. e- A&C 

(44) Which of the following is adverse effect of BDZ

  1. a- decrease Cognitive function
  2. b-Ataxia & decrease motor skills
  3. c-Addiction
  4. d- all of the following

(45) pharmacological action of flumazenil

  1. a- competitive inhibition of BDZ
  2. b- it enhances excretion of BDZ
  3. c- physiological antidote of BDZ
  4. d- prevent withdrawal effect of BDZ

enumerate:-

 1- pharmacological action of BDZs
2- adverse effects of BDZ
3- disadvantages of barbits in comparison to BDZ
4- signs of Acute toxicity of Barbiturates
5- ways of managment of barbits toxicity
6-Advantages of zolpidem over BZDs

Explain:-

1- BDZ is used in alcohol with drawal
2- BDZ is preferred over barbits
3- danger of toxicity of barbits


Answers

27 C

28 B

29 C

30 A

31 B

32 D

33 D

34 C

35 E

36 B

37 D

38 C

39 B

40 D

41 D

42 B

43 E

44 D

45  A




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