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Pathology_L3, Demyelination, degenerative & obstructive diseases

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L3, Demyelination, degenerative & obstructive diseases  




MCQ

1- Neurodegenerative diseases include the following except
a) Alzheimer disease. 
b) Parkinsonism. 
c) Huntington disease. 
d) Amyotrophic lateral sclerosis. 
e) Glioblastoma multiforme

2- Demyelinating diseases of CNS are characterized by damage to myelin and axons. 

3-Hydrocephalus may be caused by meningitis.

4- A 26-year-old woman presents to her primary care physician with a 2-week history of pain in her right eye. During the physical examination, the patient is noted to have hyperemia and edema of her right optic disc. On further questioning, the patient also complains of intermittent weakness for the past several months. Neurologic examination reveals 5/5 strength in the left upper extremity, 4/5 in the right upper extremity, 4/5 in the right lower extremity, and 5/5 in the left lower extremity. She undergoes an MRI, which is shown in the image 



Which of the following disease is the most appropriate Diagnosis
A-Amyotrophic lateral sclerosis
B-Multiple sclerosis
C-Hypertension
D-Huntington disease.
E-Parkinsonism.

Answer

1-E
2-F
3-T
4- B, Multiple sclerosis may present with optic neuritis and motor deficits that are separated by space and time. MRI demonstrates periventricular demyelinating lesions representing areas of oligodendrocyte loss and reactive gliosis.
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