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Pharmacology_L2 , Antipsychotic drugs

 L2 , Antipsychotic drugs



MCQ


1-Antiemetic action of antipsychotics is due to 
a- D receptor block in CTZ
b- D receptor block in mesolimbic system
c- D receptor agonist in basal ganglia
d- D receptor block in hypothalamus

2-Dry mouth, constipation &Urine retention during therapeutic use of antipsychotics because it have:
a- H1 receptor block
b- Alpha 2 receptor agonist
c- M receptor block 
d- D2 receptor block

3. Role of anti-cholinergic drugs with typical antipsychotic
a- To relieve extra pyramidal effect
b- To prevent Parkinsonism 
c- To prevent dystonia 
d- Non 
e- All

4. Anticholinergic drugs are contraindicated in tardive dyskinesia caused by chronic use of typical antipsychotics due to 
a- super sensitivity of D receptors
b- Exaggerated action of ACH
c- Both

 5. High potent antipsychotics are more preferred in 
a- old age 
b- Cardiac patients
c- All 
d- Non

6. Advantages of atypical antipsychotics over typical 
a- less central side effects
 b-Improve -ve symptoms only
c- Improve both negative and positive symptoms
d- a and c 

7. Olanzapine 
a- more central side effects 
b- Less central side effect
c- Cause agranulocytosis
d- More extrapyramidal effect

8. Lithium is used as
a- anti-manic
b- Mood stabilizer
c- Anti depressant
d- a and b 

10. Alternatives in lithium toxicity
a- Lamotrigin
b- Valporate
c- Both 
d- Non

11. NAHCO3 role in Li toxicity
a- decreases reabsorption in renal tubules
b- Antagonize its effect on receptors
c- Increases its excretion in bile 
d- Symptomatic TTT

12. Regarding respridone:
a- It is typical antipsychotic 
b- It is atypical antipsychotic 
c- Has more central side effect 
d- Decrease galactorrhea and gynecomastia 

13. Antipsychotic medication is sometimes prescribed to treat sleep problems or disruptive behaviors in people with dementia
a- TRUE 
b- FALSE 

14. Lithium toxicity can manifest by all except: 
a- ataxia 
b- Arrhythmia 
c- Convulsion 
d- Kinetic tremors 

 15. A 65-year-old man was brought to the hospital with complaints o pain in lower abdomen and not having passed urine for 16 hours. The bladder was found to be full. His son informed that he was depressed for the last 2 years and only the day before a doctor had given him some medicine. Which of the following drugs is he most likely to have received?
a. Chlorpromazine 
b. Haloperidol 
c. trifluperazine  
d. Trazodone



16. Most common receptor for antipsychotic drugs :
a. D1 
b. D2
c. D3 
d. D4 

17. Drug cause agranulocytosis:
 a. Risperidone
 b. Haloperidol
c. Olanzapine
d. Clozapine  

18. One of the following is not a mixed D 2 and 5HT 2A antagonist:
 a. Risperidone
 b. Olanzapine
 C. Haloperidol 
d. Clozapine 

SHORT ESSAY 

19. Explain mechanism of Action of Antipsychotics.

20. Compare between typical and atypical antipsychotic drugs

21. Mention extrapyramidal side effect of antipsychotic drugs.

22. Mention alternatives of Lithium in case of toxicity  

Answers

1.a                                     
2.c          
3.e                                    
4.c                           
5.c
6.d
7.b
8.d
10.c 
11.a
12.b 
13.a
14.d
15.a
16.b
17.d
18.c

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