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Pharmacology_L3 , Type 1 hypersensitivity

L3 , Type 1 hypersensitivity 

MCQ



1- Histamine is formed by action of .... On histidine
a-Decarboxylase
b-Hydroxylase
c-Phosphorylase
d-Aromatase


2- Histamine is stored mainly in
a-Esinophill
b-Mast cell
c-PNL
d-Macrophage


3-H2 receptors are found in
a-Exocrine glands
b-CNS
c-Inflammatory cells
d-Heart


4- Inflammatory cells contain
a-H1 receptors
b-H2 receptors
d-H3 receptors
d-H4


 5-All of the following is true about Actions of histamine except
a-Increase HCL secretion
b-Increase capillary permeability
c-Increase release from neurons
d-Increase Heart rate

6-Which of the following drugs is mast cell stabilizer
a-Adrenaline
b-Cyclizine
c-Prednisolone
d-Ketotifen

7-Which of the following drugs is histamine blocker second generation
a-Fexofenadine
b-Cyclizine
c-Antazoline
d-Meclizine


8-Regarding actions of Histamine blocker drugs ?
a-Sedation
b-Atropine like action
c-Antimotion sickness
d-All of the above


9-About H1 blocker which of the following drugs is has anti serotonin like action
a-Meclizine
b-Cyprohepatidine
c-Dimenhydrinate  
d-Carbinoxamine


10-Which of the following drugs has quinidine like action
a-Dimenhydrinate
b-Fexofenadine
c-Antazoline
d-Meclizine


11-Regarding H blocker, which of the following drugs is used in treatment of vomiting in pregnancy
a-Diphenhydramine
b-Fexofenadine 
c-Doxylamine
d-Meclizine


12-All of the following are uses of H blocker except
a-Allergy
b-Carcinoid syndrome
c-Arrythmia
d-Hypertension


13-H blocker lead to dry mouth due to
a-Alpla 1 blocker
b-Potassium channel blocker
c-Atropine like action
d-Quinidine like action


14-The major portion of Glucocorticoid is
a-Bound to albumin
b-Bound to globulin
c-Free form
d-Non of the above

15-Glucocorticoid are administered
a-Orally
b-IM
c-Topical
d-All of the above

16-From Which of the following drugs is long acting Glucocorticoid
a-Hydrocortisone
b-Prednisolone
c-Paramethasone
d-Dexamethasone


17-All of the following is true about metabolic effect of Glucocorticoid except
a-Salt and water retention
b-Hyperglycaemia
c-Protein anabolism
d-Lipolysis


18-All of the following is true about antiinflammatory action of Glucocorticoid Except
a-Stabilization of lysosomes
b-Increase capillary permeability
c-Inhibition of Antigen antibody reaction 
d-Inhibition of release of histamine


19-Occur due to prolonged intake of-Glucocorticoid
b-Marfan syndrome
c-Cushing syndrome
d-Addison's disease
e -Acute Adrenal insufficiency

20-All of the following is true about prednisolone except
a-Increase HCL
b-Growth retardation
c-Decrease ca excretion
d-Increase sensitivity of BVs to catecholamines


21-Side effects of Glucocorticoid include 
a-Myopathy
b-Osteoporosis
c-Hypokalemia
d-All of the above

22-Glucocorticoid increase HCL in stomach 
a-Increasing PG
b-Decreasing PG
c-Opening Ca channel
d-Blocking Ca channel


23-All of the following are therapeutic uses of
a-Glucocorticoid except
b-Rheumatoid arthritis
c-Anaphylactic shock
d-Peptic ulcer
e-Hemolytic anemia


24-Which of the following is drug of choice in case of anaphylactic shock
a-Adrenaline
b-Prednisolone 
c-Meclizine
d-Infliximab


25-Which of the following is used in treatment of Stevens Johnson syndrome
a-Topical steroids
b-Antibiotics
c-Analgesics
d-All of the above


26-Which of the following drugs may lead to steven Johnsen syndrome
a-Infliximab
b-Verapamil
c-Allopurinol 
d-Captopril


27-Which of the following occur in Steven Johnson syndrome
a-Rash
b-Fever
c-Conjunctivitis 
d-All of the above


28-Blood vessels contain H2 receptors
True
False


29-Adrenaline is physiological antagonist of histamine
True
False


30-Second generation of Histamine blocker can pass through BBB
True
False


31-Diphenhydramine is used in treatment of parkinsonism
True
False


32-Meclizine is contraindicated in pregnancy
True
False


33-Paramethasone is short acting Glucocorticoid
True
False

34-Glucocorticoid act by binding to cell surface receptors and cytoplasmic receptor
True
False


35-Glucocorticoid decrease total number of WBCS
True 
False


36-Steven Johnson syndrome is medical emergency
True
False


37-Complications of Stevens Johnson syndrome include pneumonia
True
False


38-Steven Johnson syndrome is type 3 hypersensitivity
True
 False

Short answers

1) histamine stored mainly in ……….

2) Non mast cells histamine is found in several tissue including the ………..

3) Site of H1 receptor ……….

4) Site of H2 receptor

5) classify glucocorticoids……

6)mechanism of action of glucocrticods….

7)mention some drugs of first generation

8)mention some drugs of second generation…….. 

9) uses of histamine antagonist………..

10)Side Effects of histamine antagonist…….
 

Answers

1- a   
2- b
3- d
4- d   
5- d 
6- d
7- a 
8- d
9- b                  
10-c                          
11- c                      
12-d
13- c 
14- b 
15-d 
16- d
17- c 
18- b 
19- b 
20- c
21-d 
22- b 
23-c 
24- a
25- d 
26-c 
27- d
28- false 
29- true 
30-false
31- true 
32- true
33- false
34- true
35- true
36- true                       
37- true
38-false      
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