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L 2 pharmacology, Anti hypertensive drugs

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MCQ

1)Which of the following is NOT from complications of
hypertension?

a)Renal failure
b)Liver cirrhosis
c)Heart failure
d)Cerebral hemorrhage.

2)To treat hypertension it is recommended to use

a)Loop diuretics
b)Vasoconstrictor drugs
c)Sympathomimetics
d)Ca channel blockers
e) a&d.

3)Which of the following will improve the peripheral
circulation

a)Restricting dietary intake
b)Ca channel blocker
c)Vasodilators
d)Diuretics.

4)Which of the following is from side effects of diuretics?

a)Hypernatremia
b)Hyperkalemia
c)Hypersensitivity
d)Hypoglycaemia

5)Diuretics work by:

a)Increasing circulatory volume.
b)Increasing peripheral resistance.
c)Vasodilatation
d)Decrease prostaglandin

6)Chlorthiazide:

a)Has vasodilator action
b)Is used in high levels of hypertension.
c)Cause hyperkalemia
d)Used in CHF
e) a&d

7)Furosemide is given..... in case of emergency.

a)Subcutaneous.
b)I.V.
c)Oral

8)Gynecomastia is from side effects of...

a)Furosemide
b)Spironolactone
c)Triametrene
d)Furosemide

9)Potassium sparing diuretics cause

a)Hyperkalemia
b)GIT upset
c)Antagonize aldosterone
d)All of the above

10) Which of the following diuretics is called aldosterone
antagonist

a)Furosemide
b)Triametrene
c)Spironolactone
d)Amiloride

11) Captopril

a)Causes hyperkalemia
b)Is safe for lactating mothers.
c)Keep your taste sensation
d)Is a loop diuretic

12) Lisinopril

a)Is an active drug
b)Is effective in CHF
c)Inhibit ACE
d)All of the above

13) Which of the following doesn’t contain SH- and is a
prodrug

a)Captopril
b)Benzepril
c)Rampiril
d)Lisnopril
e)b&c

14) From the advantages of drugs that inhibit rennin
angiotensin system

a)No reflex tachycardia
b)Safe for pregnant women
c)Causes a decrease in renal blood flow
d)Decrease V.D.

15) Losartan has more potent effect on rennin
angiotensin system because it

a)decrease bradykinin metabolism
b)blocks the final common pathway.
c)Has less hypersensitivity reaction.
d)Cause common cough.

16) Which of the following is angiotensin receptor
blocker

a)Furosemide
b)Valsartan
c)Captopril
d)Diltiazem

17) Which of the following drugs cause decrease in heart
rate

a)Nimodipine
b)Nifedipine
c)Verapamil
d)Amlodipine

18) A patient came to hospital complaining of headache
and flushing, when we measured the blood pressure it
was high and his ankle was swollen. This may be the
adverse effect of

a)Verapamil
b)Nifedipine
c)Diltiazem
d)Amlodipine

19) All of the following are from class dihydropyridine
EXCEPT

a)Nifedipine
b)Verapamil
c)Nimodipine
d)Amlodipine

20) Which of the following drugs is from Ca channel
blockers

a)Temisartan
b)Nimodipine
c)Olmesartan
d)Valsartan

True or False

1)Arterial blood pressure is directly proportional to result of
multiplication of cardiac output & the peripheral vascular. 

2)Coronary ischemia and Encephalopathy are from
complications of hypertension.

3)Chlorthalidone is used in sub diuretic dose in mild
hypertension.

4)Chlorthiazide cause hyperglycemia and hypernatremia.

5)Hydrochlorthiazide has vasoconstrictor action.

6)Furosemide is from potassium sparing diuretics.

7)Triametrene cause Gynecomastia.

8)Loop diuretics are injected I.V in emergency hypertension.

9)Lisopril is an active drug.

10) Enalapril is safe for pregnant women.

11) Captopril causes reflex tachycardia.

12) Irbesartan increase bradykinin metabolism.

13) Captopril blocks the final common pathway.

14) Candesartan increases bradykinin metabolism.

15) Verapamil increases heart rate.

16) Diltiazem is given to patients who suffer from angina.

17) Prazocin affect only arterial smooth muscle.

18) Beta adrenergic blockers decrease the release of renin

19) Hydralazine is a mixd blood dilator.

20) Minoxidil causes lupus syndrome.

21) Nitroprosside open K channels.

Short essay

1)Mention side effects of captopril.

2)Mention advantages of drugs that inhibit renin-angiotensin
system.

3)Mention the differences between angiotensin receptor
blockers & ACE1 inhibitors.

MCQ answers

1)B                        11) A
2)E                       
12) D
3)A                       
13) E
4)C                        
14) A
5)C                        
15) B
6)E                       
16) B
7)B                       
17) C
8)B                       
18) B
9)D                        
19) B
10) C                     
20) B

True or false answers

1. True                 12. False
2. True                 13. False
3. True                 14. False
4. False                15. False
5. False                16. True
6. False                17. False
7. False                18. True
8. True                 19. False
9. True                 20. False
10. False              21. False
11. False

Short essay answers

1) Side effects of captopril.
  • Cough 
  • Allergy
  • Proteinuria
  • Taste changes (loss of taste)
  • Orthostatic hypotension (initial 1st dose)
  • Pregnancy (contraindicated) → fetal anomalies
  • Rash
  • Increase K →Hyperkalemia
  • Leukopenia (Neutropenia)
2) Advantages of drugs that inhibit renin-angiotensin
system.
  • mixed dilator → no oedema
  • no refelx tachycardia
  • no decrease in renal blood flow
3) The differences between angiotensin receptor blockers
& ACE1 inhibitors
  • Angiotensin receptor blocker is similar ACEI inhibitors in pharmacological profile .They differs in:
  • No effect on bradykinin metabolism
  • More potent effect on renin angiotensin system because it blocks the final common pathway.
  • Less common cough because they do not affect bradykinin metabolism
  • Less hypersensitivity reaction


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