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L1_Cholesterol metabolism , Bio

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1_Which of the following is the key enzyme of cholesterol synthesis.............

A_HMG coA synthase 

B_HMG coA reductase 

C_7-a-hydroxylase 

D_12-a-hydroxylase 

2_Which of the following is the key enzyme for bile acid synthesis.............

A_7-a-hydroxylase 

B_12-a-hydroxylase 

C_HMG CoA synthase 

D_HMG CoA reductase 

3_All of the following are sites of cholesterol synthesis except................

A_Liver

B_Skin

C_RBCs

D_Kidney 

4_In covalent modification of HMG COA reductase, which of the following hormones decrease its activity?

A_Insulin 

B_Thyroxin

C_Glucagon

D_GH

5_Excess cholesterol causes inhibition of the proteolytic cleavage of ................

A_SREBP

B_7a-hydroxylase 

C_HMG coA synthase 

D_Thiolase 

6_All of the following are factors that decrease cholesterol plasma level except..........

A_Infection 

B_Anemia 

C_Hypothyroidism 

D_Hyperthyroidism 

7_All of the following are factors that increase cholesterol plasma level except...........

A_DM

B_Obesity 

C_Nephrosis 

D_Liver cirrhosis 

8_All of the following are 1ry bile acids except.............

A_Glycocholic 

B_Chenodeoxycholic 

C_Lithocholic 

9_Which of the following drugs is an competitive inhibitor to HMG CoA reductase..........

A_Tetracycline 

B_Statin

C_Levofloxacin 

D_Aspirin 


Answers 

B_1

A_2

C_3

C_4

A_5

C_6

D_7

C_8

B_9










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