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L6, Antidepressant drugs, Pharma

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MCQ

1)TCAs mechanism of action

a- increases NE & 5HT release
b- inhibits NE & 5HT reuptake
c- stimulate serotonin receptors
d- non of the above

2) TCAs increases 5HT concentration through

a- increasing release
b- inhibition of reuptake
c- non of the above

3) Therapeutic uses of TCAs

a- Psychic depression
b- Panic & phobic disorder
c- Obsessive compulsive disorder
d- Nocturnal enuresis in children
e- all of the above

4) Dry mouth, blurred vision, urine retention are side effects of TCAs due to

a- block of alpha receptors
b- H1 block
c- atropine-like action

5) TCAs are contraindicated in all of the above except

a- premature ejaculation
b- glaucoma
c- enlarged prostste
d- cardiac arrhythmias

6) SSRIs inhibits reuptake of …… (SSRIs=selective serotonin reuptake inhibitors)

a- serotonin (5HT)
b- NE
c- both
d- non

7-Side effects of SSRIs includes

a-Stomach upset •
b- Sexual dysfunction •
c-Serotonin syndrome •
d-Suicidal thoughts
e- all

8)SSRIs are preferred more than TCAs due to all of the following except

a- not cardio toxic
b- has atropine like action
c- no postural hypotention
d- no sedation

9)which of the following is TCAs

a-nefazodon
b-amitriptalin
c-fluoxetin
d-isocarboxazid

10) which of the followings is the therapeutic use of SSRIs

a-Depression in early stages •
b- Minor depressive illness •
c-Anxiety disorders•
d-Chronic pain
e- all

11) which of the following is not a side effect of serotonin
( Advantages of SSRIs over TCAs • No cardiotoxicity) )

a- Stomach upset
b-Sexual dysfunction •
c-Serotonin syndrome
d- cardiac arrhythmia

12)SNRIs differs from TCAs because it ….. in such question: (it refers to SNRIs)

a- increases 5HT conc.
b- used as antidepressant
c- has no effect on alpha,M&H receptors
d-non of the above

13)which of the following selectively inhibits NE reuptake

a- atomoxetin & repoxetin
b-duloxetin
c-impiramin
d- non of the following

14) selective MAOA inhibitors is used as …… while selective MAOB inhibitors is used as ………

a- antidepressant-antiparkinsonian
b- antiparkinsonian –antidepressant
c- antipsychotic-antiparkonsian

15)SSRIs with MAO inhibitors is considered

a- good combination wih less side sideeffects
b- bad combination with toxic manifestations
c- don’t affect each other

16) taking SSRIs with MAO inhibitors may cause

a- fanconi syndrome
b- Loffler syndrome
c- serotonin syndrome
d- bachet,s syndrome

17)ribe cheese(old cheese ) in patients taking MAOI may cause

a- thyrotoxicosis
b-serotonin syndrome
c- encephalopathy
d- hypertensive crisis

18)cheese reaction occurs only with (moclobemide or clorgyline are selective A)

a- selective MAOAI ( selective A don’t work on GIT)
b- selective MAOBI
c- non selective MAOI

19)which synapses are involved in depression

a- serotonergic synapses
b- cholinergic synapses
c- all of the above
d- non of the above

20) MAO inhibitors increase concentration of serotonin by

a- decrease its uptake in nerve endings
b- inhibits its degradation
c- increase its release
d- non of the following

21) the most dangerous interaction is between MAOI and ….

a- chatecholamines
b- dopamine
c- TCAs
d- SSRIs

22)TCAs are

a- highly selective serotonin reuptake inhibitor
b- mono amine oxidase inhibitor
c- selective nor epinephrine reuptake inhibitor
d- non selective NE & 5HT reuptake inhibitor

23) which antidepressant drug of the following cause less autonomic side effect

a- amitryptaline (find the selective)
b-flouxetine
c-imiperamine
d-clomipiramine

24) all are atypical antidepressants except

a- flouxetine
b-bupropion
c-mirtazapine
d-nifazodone
e- trazodone

25)lithium carbonate is used in

a- depression
b- mania
c- all
d-non

26)which of the following drugs is used for depression (exam 2020)

a-bupropion
b-haloperidol
c-mirtazapine
d- a&C
e- all

27) clomipiramine is used in TTT of all of the following except (exam 2020)

a- depression (clomipiramine&imipiramine : TCAS)
b-mania
c- OCD
d-panic disorder
e- A&C

MCQ answers

1-B

2-B

3-E

4-C

5-A

6-A

7-E

8-B

9-B

10-C

11-D

12-C

13-A

14-A

15-B

16-C

17-D

18-C

19-C

20-B

21-D

22-D

23-B

24-A

25-B

26-C

27-B



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