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L3_ Antifungal and antiviral drugs _ Pharma

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Questions 

1.which of the following drugs does not Alter cell membrane permeability
A- ketoconazole
B- amphotericin B
C-terbinafine
D-flucytosine
2.which of the following is not correct regarding nystatin
A-It is fungicidal mainly against candidiasis
B-It contains polene which bind with fungal membrane ergosterol leading to loss of selective permeability
C-It can be used orally or locally in the form of ointment in moniliasis
D-It Inhibits nucleic acid synthesis and mitosis
3-Which of the following drugs is highly toxic drug and causes renal damage, liver damage, hypokalemia
A-nystatin
B-Amphotericin B
C-terbinafine
D-flucytosine




4-Which of the following drugs when used by infusion causes fever, vomiting, headache, and hypotension
A-nystatin
B-Amphotericin B
C-terbinafine
D-flucytosine
5-Which of the following is correct regarding AmphotericinB
A-It is fungicidal
B-It is used in fungal infections especially candidiasis (IV)
C-It is used in Fungal meningitis (intrathecally)
D-It is used in in fungal corneal ulcerations (eye drops)
E-All of the above
6-which of the following is not correct regarding griseofulvin
A-It is fungistatic against dermatophyte
B-It is fungistatic against candida
C- It is used in treatment of ring worm
D- It is LME inducer
7-griseofulvin is liver microsomal enzyme inhibitor
A-True
B-False
8-which of the following is a side effect of griseofulvin
A-It is a LME inducer
B-It is a Hepatotoxic
C-It causes GIT upset
D-All of the above
9-Which of the following is not correct regarding Flucytosine
A- It is used singly
B- It is a fungistatic used in combination with Amphotericin B.
C-It causes B.M suppression
D-It causes stomatitis
10-Flucytosine inhibits DNA synthesis
A-True
B-False
11-Azoles inhibit cell wall synthesis and interfare with membrane permeability
A-True
B-False




12-Which of the following drugs is liver microsomal enzyme inhibitor
A-ketoconazole
B-griseofulvin
C-terbinafine
D-flucytosine
13-Which of the following drugs Causes gynecomastia and oligospermia
A-ketoconazole
B-griseofulvin
C-terbinafine
D-flucytosine
14-Which of the following is not correct regarding Fluconazole
A-ketoconazole is better than it
B-It is less hepatotoxic
C-It has less drug interaction
D- It is not affect sex hormones
15-Itaraconazole As fluconazole but less penetration of BBB
A-True
B-False
16-Which of the following is correct regarding Voriconazole
A-It is used in Treatment of lung aspergillosis
B-It is absorbed orally, metabolized and eliminated mainly by liver
C-It causes sever skin reaction
D-All of the above
17-To treat pulmonary candidiasis ,Amphotericin B along with flucytosine are used
A-True
B-False
18-To treat pulmonary histoplasmosis,fluconazole and itraconazole are used
A-True
B-False
19-Best responses to antiviral drugs are in patients with competent immune systems
A-True
B-False








20-Which of the following is not correct regarding gamma globulins
A-It inhibit viral nucleic acid synthesis
B-It inhibit attach or penetration of the virus into the host cell
C-It is active against (measles, polio, rabies)
D-It is from pooled plasma
21-which of the following is corrct regarding Amantadine
A- It inhibits M2 proton ion channel needed uncoating of influenza virus
B-It is given orally as a prophylaxis of influenza A
C-It can be used in treatment of Parkinsonism as it inhibit dopamine reuptake
D-All of the above
22-Remantadine is better than amantadine
A-True
B-False
23-acyclovir is nephrotoxic
A-True
B-False


24-Gancyclovir causes bone marrow depression
A-True
B-False
25-ritonavir is effective against HIV-1, HIV-2,and needs intracellular activation
A-True
B-False
26-which of the following is not true regarding ribavirin
A-It inhibits synthesis of triphosphate capsule of viral mRNA
B-It does not need intracellular activation
C-It is a broad spectrum antiviral drug
D-It has poor GIT absorption
27-which of the following is not true regarding ribavirin
A- It pass BBB
B-One of its SE is rash
C-It is contraindicated in end stage RF, IHD, pregnancy
D-It causes Inhibition of attach or penetration of the virus into the host cell




28-which of the following is correct regarding Immunomodulators (interferon)
A-It is a Glycoproteins secreted from host cells in response to viral or parasitic infection
B-It Interferes with viral: penetration, transcription, maturation, protein processing & release
C-It Increases phagocytic activity of macrophages
D-All of the above
29-which of the following is not correct regarding Immunomodulators (interferon)
A-It Increases proliferation of cytotoxic T cell
B-It is Used in treatment of hepatitis B, C
C- IT CAUSES flu like syndrome which is irreversible
D-with chronic therapy: transient hearing loss, neurotoxic, retinopathy
30-Immunomodulators (interferon) causes transient increase of liver enzymes
A-True
B-False






Anwers

1-D
2-D
3-B
4-B
5-E
6-B
7-B
8-D
9-A
10-A
11-A
12-A
13-A
14-A
15-A
16-D
17-A
18-A
19-A
20-A
21-D
22-A
23-A
24-A
25-B
26-B
27-d
28-D
29-C
30-A






















SHORT ESSAY
1-What IS the mechanism of action of GRISOFLUVIN
2-What IS the mechanism of action of FLOCYTOCINE
3-What IS the mechanism of action of AZOLES
4- What IS the mechanism of action of RIBAVIRIN
5- WHAT ARE THE MECHANISM OF ACTION AND SE OF AMANTADINE
6- WHAT ARE THE MECHANISM OF ACTION AND SE OF IMMUNOMODULATOR























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