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L2, pharmacokinetics 1(Distribution), pharmacology

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MCQ 

1. All the following statements about distribution of drugs are Correct Except:
A. The passage of drugs from the capillaries to the cells is multi-compartmental distribution
B. Intravascular & interstitial distribution is Two compartmental distribution 
C. If the drug remains inside the vessels this called intravascular distribution
D. Quaternary Ammonium compounds can 
easily pass into the cells

2. Plasma protein binding is:
A. Irreversible
B. Basic drugs bind mainly to plasma albumin 
C. A site of some drug interactions 
D. All of the above
3. Drug pass in 2 compartment pass in both ECF and ICF:
A. True
B. False
4. Most of drugs are distributed homogeneously:
A. True 
B. False
5. Biological barriers include all except:
A. Renal tubules
B. Cell membranes
C. Capillary walls
D Placenta barrier

6. What is the reason of complicated penetration of some drugs through brain-blood barrier?
A. High lipid solubility of a drug
B. Meningitis of pores in the brain endothelium
C. Absense of pores in the brain capillaries endothelium 
D. High endocytosis degree in a brain capillary

7. The volume of distribution (V) relates:
 
A. Single to a daily dose of an administrated drug
B. An administrated dose to a body weight 
C. An uncharged drug reaching the systemic circulation 
D. The amount of a drug in the body to the concentration of a drug in plasma
8. NH3 is also called:
A. Neostigmine
B. Histostigmine
C. Physostigmine
D. Parastigmine
9. Toxicity with drug with high affinity to plasma proteins can be treated by renal Dialysis:
A. True
B. False
10. Mannitol is from which type of distribution:
A. Single compartment
B. Two compartment
C. Multiple compartment
D. Tissue reservoir False
11. Insulin can pass BBB in normal conditions:
A. True
B. False
12. Basic drugs bind to:
A. Albumin
B. Alpha one glycoprotein
C. Globulin
13. Warfarin binds to:
A. Albumin
B. Alpha one glycoprotein
C. Globulin
14. Ca is contraindicated with:
A. Heparin
B. Dextran
C. Sulphonamide
D. Tetracycline
15. Thalidomide leads to:
A. Neonatal asphyxia
B. Phocomelia
C. Spina bifida
D. Cleft palate
16. Sulphonamide displace dicumarol leading to hypercoagulability:
A. True
B. Fals

17. Drug with rapid dissociation can displace other with slow dissociation from plasma proteins:
A. True
B. False
18. Drug with low Vd has all EXCEPT:
A. Low distribution
B. High excretion
C. High loading dose
D. Dialysis is useful
19. Free fraction of drug act as reservoir:
A. True
B. False
20. Parkinsonism is treated by Dopamine tablet because dopamine can pass BBB:
A. True
B. False
21. For the calculation of the volume of distribution (Vd) one must take into account:
A. Concentration of a substance in plasma 
B. Concentration of substance in urine
C. Therapeutical width of drug action 
D. A daily dose of drug

Answer 

1. D
2. C
3. B
4. B
5. A
6. C
7. D
8. C
9. A
10. B
11. B
12. B
13. A
14. D
15. B
16. B
17. B
18. C
19. B
20. B
21. A
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