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L9&10, adrenergic pharmacology (sympatholytics), pharmacology

 Lecture video 



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Mcq

1-Adverse reactions of beta adrenoceptor blockers include all of the following EXCEPT:

a-bronchospasm

b-heart failure

c-AV block

d-parkinsonism

e-cold extremities

2-Beta adrenergic blockers lower intraocular tension by:

a-Down regulating adenylyl cyclase in ciliary body through reduced activation of β2 adreno-rceptors

b-Constricting ciliary blood vessels

c-Blocking adrenergic action on trabecular meshwork

d-Reducing aqueous formation unrelated to beta adrenoceptor mediation

3-Propranolol does not block the following action of adrenaline:

a-Bronchodilatation

b-Lipolysis

c-Muscle tremor

d-Mydriasis

4-In hyperthyroidism, β adrenergic blockers are used:

a-To induce euthyroid state

b-As definitive therapy

c-For rapid control of certain symptoms while awaiting response to carbimazole

d-To reduce basal metabolic rate

5-Which one of the following is a cardio selective ẞ1-blocker:

a-Timolol

c-Nadolol

b-Metoprolol

d-Sotalol

6-Which of the following is preferred in patient of pheochromocytoma:

a- Labetalol

b- Prazosin

c- Clonidine

d- Propranolol


7-Which one of the following drugs will produce the strongest reflex tachycardia effect:

a- Prazosin.

b- Doxazosin

c- Tamsulosin

d- Phenoxybenzamine

8-Phentolamine has all of the following pharmacological actions EXCEPT:

a-alpha-receptors blocking action

b-histamine like action

c-cardiac stimulant action

d-anti-serotonin action

e-vasoconstrictor action

9-Which of the following is correct regarding α-adrenergic blockers?

a-α-Adrenergic blockers are used in the treatment of hypotension in anaphylactic shock:

b- α-Adrenergic blockers are used in the treatment of benign prostatic hyperplasia .

c- α-Adrenergic blockers reduce the frequency of urination.

d- α-Adrenergic blockers may cause bradycardia


10-Indicate the irreversible alpha receptor antagonist:

a) Tolazoline

b) Labetalol

c) Prazosin

d) Phenoxybenzamine

11-Which of the following α- blockers is non selective?

a- phenoxybenzamine

b- Prazocin

c- Terazosin.

d- Tamulosin

12-α- blocker without any effect on blood pressure:

a- Prazosin

b- Tamsulosin

c- Oxazosin

d- Terazosin

Answers of mcq

1-d

2-a

3-d

4-c

5-b

6-a

7-d

8-a

9-b

10-d

11-b

12-b

 Written questions

1-Describe how propranolol affect Metabolism.

2-list 3 or 4 uses for propranolol.

3-describe why phenoxybenzamine used as antishock.

4- write what you know about Labetolol.

Answers of written questions

 1-inhibit B in liver so decrease glycogenolysis and decrease renin release from kidney so cause hyperkalemia

2-Acute myocardial infarction,Arrhythmias, Thyrotoxicosis, esophageal varices

3-block α receptor and decrease release of ADH resulting in vasodilation so improve tissue perfusion

4-Block α1 and B receptor,Produce quick drop in Bp ,dosen’t produce tachycardia ,Used in treatment of hypertension (emergency)also used in hypertension due to pheochromocytoma
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