Tut 3, Chemotherapy, Pharmacology

 Lecture video 




      1- Which of the following drugs inhibit di – d – alanine : 

 a- Cycloserine
b- vancomycin
c- ceftriaxone
d- penicillin

2- Which of the following regarded to action of polymixins : 
a- Increasing cell permeability to cause cell damage
b- cell wall synthesis inhibitor
c- inhibiting protein synthesis
d- inhibiting nucleic acid metabolism
 3- Metronidazole affects : 
a- DNA
b- RNA
c- RNA and DNA
d- mRNA
4- A 57 years old male came to Benha
University Hospitals , Emergency department
suffering from Nausea , Vomiting , Diarrhea . From the history he told the physician
he was suspected to be COVID 19 patient . one of the drugs in COVID – 19 protocol have
specific toxicity effect . Which of the following drugs may be the drug that the patient took :

a- Erythromycin
b- Chloroquine
c- Ceftriaxone
d- metronidazole

5- Deafness and Vertigo the most common side effect of :
a- Sterptomycin
b- Erythromycin
c- Chloroquine
d- Tetracycline


Answer of all Question is (A)

Short Essay 

1- Enumerate examples of Specific toxicity in drugs of antimicrobial agents .

2- Enumerate Classification of antimicrobial agents according to mechanisms

3- Compare between broad spectrum and narrow spectrum antimicrobial agents

Short essay Answer 

1_ Sulphonamides: Crystalluria, Hemolytic anemias in G-6-PD deficiency. →Penicillins: Allergy, Herxheimer reaction.
→Cephalosporins: Allergy, nephrotoxic.
→Erythromycin: Nausea, vomiting, diarrhoea, cholestatic jaundice.
→Chloramphenicol: Bone marrow depression, Grey baby syndrome. →Streptomycin(aminoglycosides): Deafness & vertigo (8th nerve affection), Curare-like action.
→Tetracyclines : Teratogenic & G.I.T. irritation (nausea, vomiting) Teeth (enamel hypoplasia, yellow discolouration). →INH: Peripheral neuropathy

2_Cell wall synthesis inhibitor - Increasing permeability of cytoplasmic membrane leading to damage - Inhibiting protein synthesis - Inhibiting Nucleic acid metabolism

3-.    broad spectrum :
1- Effective against multiple gram +ve & -ve organisms e.g: quinolones.
2- Used as initial empirical treatment till culture and sensitivity results appear.

     - Narrow spectrum :
1- Effective against specific organisms e.g:
2- Antimicrobial against gram +ve bacteria: Penicillin G.
3- Antimicrobial against gram -ve bacteria: aminoglycosides.
4- Used in treatment of susceptible organisms based on culture and sensitivity results.